Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Denis Ptchelkine; Ashley Gillum; Tomohiro Mochizuki; Soizick Lucas-Staat; Ying Liu; Mart Krupovic; Simon E. V. Phillips; David Prangishvili; Juha T. Huiskonen

doi:10.1038/s41467-017-01668-0

Nature Communications (Nov 2017)

Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging

Denis Ptchelkine,
Ashley Gillum,
Tomohiro Mochizuki,
Soizick Lucas-Staat,
Ying Liu,
Mart Krupovic,
Simon E. V. Phillips,
David Prangishvili,
Juha T. Huiskonen

Affiliations

Denis Ptchelkine: Weatherall Institute of Molecular Medicine, University of Oxford
Ashley Gillum: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
Tomohiro Mochizuki: Department of Microbiology, Institut Pasteur
Soizick Lucas-Staat: Department of Microbiology, Institut Pasteur
Ying Liu: Department of Microbiology, Institut Pasteur
Mart Krupovic: Department of Microbiology, Institut Pasteur
Simon E. V. Phillips: Research Complex at Harwell, Rutherford Appleton Laboratory
David Prangishvili: Department of Microbiology, Institut Pasteur
Juha T. Huiskonen: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford

DOI: https://doi.org/10.1038/s41467-017-01668-0
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 6

Abstract

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The rod-shaped virus APBV1 is among the most thermostable viruses known. Here, Ptchelkine et al. determine its structure at near-atomic resolution, show that the DNA is packed as left-handed superhelix and identify extended hydrophobic interfaces that likely contribute to the extreme thermostability of the capsid.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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