Early KPC-Producing Klebsiella pneumoniae Bacteremia among Intensive Care Unit Patients Non-Colonized upon Admission

Matthaios Papadimitriou-Olivgeris; Fotini Fligou; Iris Spiliopoulou; Christina Bartzavali; Vasiliki Dodou; Sophia Vamvakopoulou; Kyriaki Koutsileou; Anastasia Zotou; Evangelos D. Anastassiou; Myrto Christofidou; Markos Marangos

doi:10.5604/01.3001.0010.7863

Polish Journal of Microbiology (Jun 2017)

Early KPC-Producing Klebsiella pneumoniae Bacteremia among Intensive Care Unit Patients Non-Colonized upon Admission

Matthaios Papadimitriou-Olivgeris,
Fotini Fligou,
Iris Spiliopoulou,
Christina Bartzavali,
Vasiliki Dodou,
Sophia Vamvakopoulou,
Kyriaki Koutsileou,
Anastasia Zotou,
Evangelos D. Anastassiou,
Myrto Christofidou,
Markos Marangos

Affiliations

Matthaios Papadimitriou-Olivgeris: Division of Infectious Diseases, School of Medicine, University of Patras, Greece
Fotini Fligou: Division of Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Greece
Iris Spiliopoulou: Department of Microbiology, School of Medicine, University of Patras, Greece
Christina Bartzavali: Department of Microbiology, School of Medicine, University of Patras, Greece
Vasiliki Dodou: Intensive Care Unit, Saint Andrew’s General Hospital of Patras, Greece
Sophia Vamvakopoulou: Department of Microbiology, School of Medicine, University of Patras, Greece
Kyriaki Koutsileou: Division of Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Greece
Anastasia Zotou: Division of Anaesthesiology and Intensive Care Medicine, School of Medicine, University of Patras, Greece
Evangelos D. Anastassiou: Department of Microbiology, School of Medicine, University of Patras, Greece
Myrto Christofidou: Department of Microbiology, School of Medicine, University of Patras, Greece
Markos Marangos: Division of Infectious Diseases, School of Medicine, University of Patras, Greece

DOI: https://doi.org/10.5604/01.3001.0010.7863
Journal volume & issue: Vol. 66, no. 2

Abstract

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Among 140 patients colonized by KPC-producing Klebsiella pneumoniae (KPC-Kp) between fourth and seventh day of Intensive Care Unit stay, 24 developed bacteraemia immediately after colonization. Colistin-resistance of the colonizing isolate was the factor significantly associated with early KPC-Kp bacteraemia (P < 0.001; OR 6.6, 95% CI 2.4–18.4), a worrisome finding since infections by colistin-resistant isolates is associated with increased mortality due to limited remaining therapeutic options.

Published in Polish Journal of Microbiology

ISSN: 1733-1331 (Print); 2544-4646 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Science: Biology (General): Genetics; Science: Microbiology
Website: https://www.sciendo.com/journal/PJM

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Abstract

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