Sodium Butyrate in The Treatment of Irritable Bowel Syndrome KG

Abstract

Purpose of the research: The purpose of this study is to present current knowledge on the use of sodium butyrate in the treatment of irritable bowel syndrome (IBS), with a particular focus on its effects on the microbiota and intestinal barrier. Material and Methods: The study is based on a review of the scientific literature, including clinical and experimental studies on the effects of sodium butyrate on the gastrointestinal tract. Results: Sodium butyrate strengthens the intestinal barrier, exhibits anti-inflammatory effects and influences the microbiota. Clinical studies confirm that its supplementation reduces abdominal pain, improves bowel rhythm and reduces bloating in IBS patients, resulting in a better quality of life. Conclusions: Sodium butyrate has the potential to be an effective support for IBS therapy, but further research is needed to determine its long-term safety and optimal dosage. In addition, changes in faecal levels of short-chain fatty acids (SCFAs) may act as a potential biomarker for IBS, but extra studies are needed to confirm their diagnostic value and define accurate reference levels.

Keywords

• sodium butyrate
• irritable bowel syndrome
• butyric acid
• SCFAs