Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors

Abstract

The decline in neurogenesis following birth is accompanied with a quiescent state characteristic of neural progenitors of the adult brain. Here, the authors identify the Wnt pathway antagonist SFRP1 as a potential signal that promotes quiescence and show that its inhibition stimulates stem cell activation.