Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR

Abstract

A master promoter of cell growth, mammalian target of rapamycin (mTOR) is upregulated in a large percentage of cancer cells. Still, targeting mTOR using rapamycin has a limited outcome in patients. Our recent results highlight the additional role of mTOR as a tumor suppressor, explaining these modest results in the clinic.

Keywords

• α-ketoglutarate
• autophagy
• cancer metabolism
• glutamoptosis
• mtorc1
• rapamycin