Influence of nonsteroid anabolic inosine on manifestation of the effects of dexamethasone on skeletal muscle of white rats

Abstract

In experiments on young rat females, it has been established, that the nonsteroid anabolic inosine caused in the case of complex application with dexamethasone the increasing of a specific fraction of slow or intermediate type of fibers in initially mixed forward tibial muscle upon termination of the 1.5–2 months of introduction. That results to a decrease of the most achievement amplitude of muscle’s contraction against lengthe­ning of the period of its maximum steady working capacity. Moreover, inosine prevented a decrease of muscular weight and the stability of muscle to fatigue development, which were observed in case of the isolated chronic introduction of dexamethasone.

Keywords

• dexamethasone
• inosine
• skeletal muscle
• solitary muscle’s contraction