PLoS ONE (Jan 2016)

Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.

  • Marta Stasiak,
  • Joanna Boncela,
  • Corinne Perreau,
  • Konstantina Karamanou,
  • Aurore Chatron-Colliet,
  • Isabelle Proult,
  • Patrycja Przygodzka,
  • Shukti Chakravarti,
  • François-Xavier Maquart,
  • M Anna Kowalska,
  • Yanusz Wegrowski,
  • Stéphane Brézillon

DOI
https://doi.org/10.1371/journal.pone.0150226
Journal volume & issue
Vol. 11, no. 3
p. e0150226

Abstract

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Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.