Recent advances and prospective researches on molecular epidemiology of dengue viruses

Abstract

The determination of amino acid changes in the envelop protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variations in the envelope protein-gene and virus virulence is discussed.

Keywords

• dengue virus
• molecular epidemiology
• sequencing
• envelope protein