The Effect of Pentoxiphylin on Histological Changes of Testis and Spermatogenesis Indexes in Mouse Treated With Dexamethasone

Abstract

Background and Objectives: Dexamethasone is one of the common drugs, which is used in the human severe allergies and can cause defect in the reproductive system by inducing oxidative stress. In this study, the effect of pentoxifylline as a potent antioxidant, was investigated on changes in testicular tissue and spermatogenesis indices in mice treated with dexamethasone. Methods: In this experimental study, 24 adult male Naval Medical Research Institute (NMRI) mice weighing 35±2g, were randomly divided into 4 groups (n=6 each group): control, dexamethasone (7mg/kg/day), dexamethasone+pentoxifylline, and pentoxifylline (200mg/kg/day). After 7 days of intraperitoneal injections, the mice were dissected and their right testis, were removed for stereological assessments and estimation of spermatogenesis indices. Then, serum level of testosterone, was measured. Data were analyzed using one way ANOVA and Tukey’s test at the significance level of p0.05). Conclusion: The result of this study revealed that simultaneous treatment with pentoxifylline and dexamethasone can prevent the adverse effects of dexamethasone on testis and spermatogenesis indices.

Keywords

• pentoxifylline
• dexamethasone
• testis
• spermatozoa
• mouse