From tumorigenesis to cell death: the aneuploidy paradox

Abstract

Aneuploidy, an abnormal chromosome number, is a hallmark of cancer. We recently showed that depletion of microtubule-associated protein ATIP3 (AT2 receptor-interacting protein 3) induces aneuploidy and sensitizes breast cancer cells to taxanes. Combining taxane treatment with ATIP3 depletion cooperates to reach a detrimental level of aneuploidy.

Keywords

• breast cancer
• mtus1
• atip3
• predictive biomarker
• taxanes
• multipolar spindle
• centrosome amplification
• chromosome instability