Advances on the role of PTTG1 in the pathogenesis of tumors

WU Nianping, HUANG Huili, ZHOU Kuaile, ZHOU Cefan, TANG Jingfeng

doi:10.16352/j.issn.1001-6325.2023.09.1448

Jichu yixue yu linchuang (Sep 2023)

Advances on the role of PTTG1 in the pathogenesis of tumors

WU Nianping, HUANG Huili, ZHOU Kuaile, ZHOU Cefan, TANG Jingfeng

Affiliations

WU Nianping, HUANG Huili, ZHOU Kuaile, ZHOU Cefan, TANG Jingfeng: 1. Department of Biomedical Sciencese, Institute of Biomedical Research School of Biological Engineering and Food; 2. National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068; ;3. Department of Surgery, Guixi People's Hospital, Guixi 335400, China

DOI: https://doi.org/10.16352/j.issn.1001-6325.2023.09.1448
Journal volume & issue: Vol. 43, no. 9
pp. 1448 – 1452

Abstract

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Pituitary tumor transforming gene 1(PTTG1) is an oncogene which isolated from the pituitary gland. PTTG1 was previously reported to bind and inhibit separase to affect sister chromatid separation and lead to chromosome aneuploidy, activate the DNA damage response pathway to induce p53-dependent senescence, and also transactivate some oncogenes and promote cell transformation and tumorigenesis in nude mice. It can also promote tumor growth and invasion by affecting Wnt/β-catenin, epithelial-mesenchymal transition(EMT), and TGFβ/SMAD3 pathways. This article provides ideas for the development of tumor therapeutic drugs targeting PTTG1.

pituitary tumor transforming gene 1(pttg1)|mechanism|tumor

Published in Jichu yixue yu linchuang

ISSN: 1001-6325 (Print)
Publisher: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Country of publisher: China
LCC subjects: Medicine
Website: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/1001-6325/home.shtml

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Abstract

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