GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection

Hua Yuan; Jinru Zhang; Yujuan Cai; Sheng Wu; Kui Yang; H. C. Stephen Chan; Wei Huang; Wen-Bing Jin; Yan Li; Yue Yin; Yasuhiro Igarashi; Shuguang Yuan; Jiahai Zhou; Gong-Li Tang

doi:10.1038/s41467-017-01508-1

Nature Communications (Nov 2017)

GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection

Hua Yuan,
Jinru Zhang,
Yujuan Cai,
Sheng Wu,
Kui Yang,
H. C. Stephen Chan,
Wei Huang,
Wen-Bing Jin,
Yan Li,
Yue Yin,
Yasuhiro Igarashi,
Shuguang Yuan,
Jiahai Zhou,
Gong-Li Tang

Affiliations

Hua Yuan: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Jinru Zhang: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yujuan Cai: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Sheng Wu: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Kui Yang: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
H. C. Stephen Chan: Faculty of Life Sciences, University of Bradford
Wei Huang: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Wen-Bing Jin: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yan Li: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yue Yin: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yasuhiro Igarashi: Biotechnology Research Center, Toyama Prefectural University
Shuguang Yuan: Laboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Jiahai Zhou: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Gong-Li Tang: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-017-01508-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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GyrI-like proteins are small-molecule binding proteins that are widely distributed in prokaryotes and eukaryotes, with functions that are poorly characterized. Here, the authors identify GyrI-like proteins as cyclopropanoid cyclopropyl hydrolases that can confer resistance to cytotoxic cyclopropanoid compounds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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