Nature Communications (Apr 2022)
Astroblastomas exhibit radial glia stem cell lineages and differential expression of imprinted and X-inactivation escape genes
- Norman L. Lehman,
- Nathalie Spassky,
- Müge Sak,
- Amy Webb,
- Cory T. Zumbar,
- Aisulu Usubalieva,
- Khaled J. Alkhateeb,
- Joseph P. McElroy,
- Kirsteen H. Maclean,
- Paolo Fadda,
- Tom Liu,
- Vineela Gangalapudi,
- Jamie Carver,
- Zied Abdullaev,
- Cynthia Timmers,
- John R. Parker,
- Christopher R. Pierson,
- Bret C. Mobley,
- Murat Gokden,
- Eyas M. Hattab,
- Timothy Parrett,
- Ralph X. Cooke,
- Trang D. Lehman,
- Stefan Costinean,
- Anil Parwani,
- Brian J. Williams,
- Randy L. Jensen,
- Kenneth Aldape,
- Akshitkumar M. Mistry
Affiliations
- Norman L. Lehman
- Department of Pathology and Laboratory Medicine, University of Louisville
- Nathalie Spassky
- Institut de Biologie de l’ENS (IBENS), Inserm, CNRS, École Normale Supérieure, PSL Research University
- Müge Sak
- Department of Pathology and Laboratory Medicine, University of Louisville
- Amy Webb
- Department of Biomedical Informatics, The Ohio State University
- Cory T. Zumbar
- Department of Pathology and Laboratory Medicine, University of Louisville
- Aisulu Usubalieva
- Department of Biomedical Informatics, University of Arkansas for Medical Sciences
- Khaled J. Alkhateeb
- Department of Pathology and Laboratory Medicine, University of Louisville
- Joseph P. McElroy
- Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University
- Kirsteen H. Maclean
- NanoString Technologies
- Paolo Fadda
- Department of Cancer Biology, The Ohio State University
- Tom Liu
- Solid Tumor Translational Science, The Ohio State University
- Vineela Gangalapudi
- Laboratory of Pathology, Center for Cancer Research, National Cancer Institute
- Jamie Carver
- Department of Pathology and Laboratory Medicine, University of Louisville
- Zied Abdullaev
- Laboratory of Pathology, Center for Cancer Research, National Cancer Institute
- Cynthia Timmers
- Solid Tumor Translational Science, The Ohio State University
- John R. Parker
- Department of Pathology and Laboratory Medicine, University of Louisville
- Christopher R. Pierson
- Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital
- Bret C. Mobley
- Department of Pathology, Microbiology and Immunology, Vanderbilt University
- Murat Gokden
- Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences
- Eyas M. Hattab
- Department of Pathology and Laboratory Medicine, University of Louisville
- Timothy Parrett
- Department of Pathology and Anatomic Sciences, University of Missouri
- Ralph X. Cooke
- Department of Pathology, The Ohio State University
- Trang D. Lehman
- Department of Family and Community Medicine, Contra Costa County Health System
- Stefan Costinean
- Department of Pathology, Banner Gateway Medical Center, MD Anderson Cancer Center
- Anil Parwani
- Department of Pathology, The Ohio State University
- Brian J. Williams
- Department of Neurosurgery, University of Louisville
- Randy L. Jensen
- Department of Neurosurgery, University of Utah
- Kenneth Aldape
- Laboratory of Pathology, Center for Cancer Research, National Cancer Institute
- Akshitkumar M. Mistry
- Department of Neurological Surgery, Vanderbilt University
- DOI
- https://doi.org/10.1038/s41467-022-29302-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Astroblastoma (AB) is an uncommon brain tumour and its origin remains unknown. Here, the authors perform integrative molecular analysis of 35 AB-like tumours and provide evidence that these arise in the context of epigenetic and genetic changes in neural progenitors occurring during brain development.
