Frontiers in Immunology (Oct 2018)
Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors
- Alexey N. Davydov,
- Anna S. Obraztsova,
- Anna S. Obraztsova,
- Mikhail Y. Lebedin,
- Maria A. Turchaninova,
- Maria A. Turchaninova,
- Maria A. Turchaninova,
- Dmitriy B. Staroverov,
- Dmitriy B. Staroverov,
- Ekaterina M. Merzlyak,
- Ekaterina M. Merzlyak,
- George V. Sharonov,
- George V. Sharonov,
- Olga Kladova,
- Mikhail Shugay,
- Mikhail Shugay,
- Mikhail Shugay,
- Mikhail Shugay,
- Olga V. Britanova,
- Olga V. Britanova,
- Olga V. Britanova,
- Dmitriy M. Chudakov,
- Dmitriy M. Chudakov,
- Dmitriy M. Chudakov,
- Dmitriy M. Chudakov,
- Dmitriy M. Chudakov
Affiliations
- Alexey N. Davydov
- Adaptive Immunity Group, Central European Institute of Technology, Brno, Czechia
- Anna S. Obraztsova
- Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia
- Anna S. Obraztsova
- Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia
- Mikhail Y. Lebedin
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- Maria A. Turchaninova
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- Maria A. Turchaninova
- Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow, Russia
- Maria A. Turchaninova
- Laboratory of Genomics of Antitumor Adaptive Immunity, Privolzhsky Research Medical University, Nizhny Novgorod, Russia
- Dmitriy B. Staroverov
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- Dmitriy B. Staroverov
- Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow, Russia
- Ekaterina M. Merzlyak
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- Ekaterina M. Merzlyak
- Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow, Russia
- George V. Sharonov
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- George V. Sharonov
- Laboratory of Genomics of Antitumor Adaptive Immunity, Privolzhsky Research Medical University, Nizhny Novgorod, Russia
- Olga Kladova
- Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow, Russia
- Mikhail Shugay
- Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia
- Mikhail Shugay
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- Mikhail Shugay
- Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow, Russia
- Mikhail Shugay
- Laboratory of Genomics of Antitumor Adaptive Immunity, Privolzhsky Research Medical University, Nizhny Novgorod, Russia
- Olga V. Britanova
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- Olga V. Britanova
- Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow, Russia
- Olga V. Britanova
- Laboratory of Genomics of Antitumor Adaptive Immunity, Privolzhsky Research Medical University, Nizhny Novgorod, Russia
- Dmitriy M. Chudakov
- Adaptive Immunity Group, Central European Institute of Technology, Brno, Czechia
- Dmitriy M. Chudakov
- Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia
- Dmitriy M. Chudakov
- Genomics of Adaptive Immunity Department, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
- Dmitriy M. Chudakov
- Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow, Russia
- Dmitriy M. Chudakov
- Laboratory of Genomics of Antitumor Adaptive Immunity, Privolzhsky Research Medical University, Nizhny Novgorod, Russia
- DOI
- https://doi.org/10.3389/fimmu.2018.02309
- Journal volume & issue
-
Vol. 9
Abstract
Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination. In present study we employed 5′RACE UMI-based full length and nearly error-free immunoglobulin profiling to compare plasma cell antibody repertoires in young (19–26 years) and middle-age (45–58 years) individuals vaccinated with a live yellow fever vaccine, modeling a newly encountered pathogen. Our analysis has revealed age-related differences in the responding antibody repertoire ranging from distinct IGH CDR3 repertoire properties to differences in somatic hypermutation intensity and efficiency and antibody lineage tree structure. Overall, our findings suggest that younger individuals respond with a more diverse antibody repertoire and employ a more efficient somatic hypermutation process than elder individuals in response to a newly encountered pathogen.
Keywords