Magnetic Resonance Imaging Features Associated with a High and Low Expression of Tumor-Infiltrating Lymphocytes: A Stratified Analysis According to Molecular Subtypes

Jiejie Zhou; Yi Jin; Haiwei Miao; Shanshan Lu; Xinmiao Liu; Yun He; Huiru Liu; Youfan Zhao; Yang Zhang; Yan-Lin Liu; Zhifang Pan; Jeon-Hor Chen; Meihao Wang; Min-Ying Su

doi:10.3390/cancers15235672

Cancers (Nov 2023)

Magnetic Resonance Imaging Features Associated with a High and Low Expression of Tumor-Infiltrating Lymphocytes: A Stratified Analysis According to Molecular Subtypes

Jiejie Zhou,
Yi Jin,
Haiwei Miao,
Shanshan Lu,
Xinmiao Liu,
Yun He,
Huiru Liu,
Youfan Zhao,
Yang Zhang,
Yan-Lin Liu,
Zhifang Pan,
Jeon-Hor Chen,
Meihao Wang,
Min-Ying Su

Affiliations

Jiejie Zhou: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Yi Jin: Department of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Haiwei Miao: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Shanshan Lu: Department of Pathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Xinmiao Liu: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Yun He: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Huiru Liu: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Youfan Zhao: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Yang Zhang: Department of Radiological Sciences, University of California, Irvine, CA 92697, USA
Yan-Lin Liu: Department of Radiological Sciences, University of California, Irvine, CA 92697, USA
Zhifang Pan: Zhejiang Engineering Research Center of Intelligent Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Jeon-Hor Chen: Department of Radiological Sciences, University of California, Irvine, CA 92697, USA
Meihao Wang: Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
Min-Ying Su: Department of Radiological Sciences, University of California, Irvine, CA 92697, USA

DOI: https://doi.org/10.3390/cancers15235672
Journal volume & issue: Vol. 15, no. 23
p. 5672

Abstract

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A total of 457 patients, including 241 HR+/HER2− patients, 134 HER2+ patients, and 82 TN patients, were studied. The percentage of TILs in the stroma adjacent to the tumor cells was assessed using a 10% cutoff. The low TIL percentages were 82% in the HR+ patients, 63% in the HER2+ patients, and 56% in the TN patients (p p p = 0.031); homogeneous enhancement was mostly seen in HR+ (p p p p = 0.029) and more likely to present the circumscribed margin (19%) than those with low TILs (2%, p = 0.009).

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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Abstract

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