Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

M. Rezaa Mohammadi; Samuel Mathew Rodriguez; Jennifer Cam Luong; Shiri Li; Rui Cao; Hamad Alshetaiwi; Hien Lau; Hayk Davtyan; Mathew Blurton Jones; Mahtab Jafari; Kai Kessenbrock; S. Armando Villalta; Paul de Vos; Weian Zhao; Jonathan R. T. Lakey

doi:10.1038/s42003-021-02229-4

Communications Biology (Jun 2021)

Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

M. Rezaa Mohammadi,
Samuel Mathew Rodriguez,
Jennifer Cam Luong,
Shiri Li,
Rui Cao,
Hamad Alshetaiwi,
Hien Lau,
Hayk Davtyan,
Mathew Blurton Jones,
Mahtab Jafari,
Kai Kessenbrock,
S. Armando Villalta,
Paul de Vos,
Weian Zhao,
Jonathan R. T. Lakey

Affiliations

M. Rezaa Mohammadi: Department of Materials Science and Engineering, University of California Irvine
Samuel Mathew Rodriguez: Sue and Bill Stem Cell Center, University of California Irvine
Jennifer Cam Luong: Sue and Bill Stem Cell Center, University of California Irvine
Shiri Li: Department of Biomedical Engineering, University of California Irvine
Rui Cao: Sue and Bill Stem Cell Center, University of California Irvine
Hamad Alshetaiwi: Department of Biological Chemistry, University of California Irvine
Hien Lau: Sue and Bill Stem Cell Center, University of California Irvine
Hayk Davtyan: Sue and Bill Stem Cell Center, University of California Irvine
Mathew Blurton Jones: Sue and Bill Stem Cell Center, University of California Irvine
Mahtab Jafari: Department of Pharmaceutical Sciences, University of California Irvine
Kai Kessenbrock: Department of Biological Chemistry, University of California Irvine
S. Armando Villalta: Institute for Immunology, University of California Irvine
Paul de Vos: Department of Pathology and Medical Biology, Section Immunoendocrinology, University of Groningen, University Medical Center Groningen
Weian Zhao: Sue and Bill Stem Cell Center, University of California Irvine
Jonathan R. T. Lakey: Sue and Bill Stem Cell Center, University of California Irvine

DOI: https://doi.org/10.1038/s42003-021-02229-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 17

Abstract

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Mohammadi et al. show that the transplantation of pancreatic islets within mesenchymal-stem cell (MSC) exosome-loaded hybrid alginate microcapsules in diabetic mice lead to diminished immune-based foreign body response and hyperglycemia control. This is due to immunomodulatory behavior of MSC exosomes at the engraftment site where they exert local immunosuppressive effects.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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