Nature Communications (Feb 2018)
EGFL7 reduces CNS inflammation in mouse
- Catherine Larochelle,
- Timo Uphaus,
- Bieke Broux,
- Elizabeth Gowing,
- Magdalena Paterka,
- Laure Michel,
- Nevenka Dudvarski Stankovic,
- Frank Bicker,
- Florent Lemaître,
- Alexandre Prat,
- Mirko H. H. Schmidt,
- Frauke Zipp
Affiliations
- Catherine Larochelle
- Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz
- Timo Uphaus
- Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz
- Bieke Broux
- Neuroimmunology Unit, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
- Elizabeth Gowing
- Neuroimmunology Unit, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
- Magdalena Paterka
- Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz
- Laure Michel
- Neuroimmunology Unit, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
- Nevenka Dudvarski Stankovic
- Molecular Signal Transduction Laboratories, Institute of Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz
- Frank Bicker
- Molecular Signal Transduction Laboratories, Institute of Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz
- Florent Lemaître
- Neuroimmunology Unit, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
- Alexandre Prat
- Neuroimmunology Unit, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
- Mirko H. H. Schmidt
- Molecular Signal Transduction Laboratories, Institute of Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz
- Frauke Zipp
- Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz
- DOI
- https://doi.org/10.1038/s41467-018-03186-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Endothelial cells release extracellular matrix components that regulate inflammation. Here the authors demonstrate that the extracellular matrix component epidermal growth factor-like protein 7 regulates inflammation in experimental autoimmune encephalomyelitis in the mouse.
