Nature Communications (Jun 2021)

Machine-learning predicts genomic determinants of meiosis-driven structural variation in a eukaryotic pathogen

  • Thomas Badet,
  • Simone Fouché,
  • Fanny E. Hartmann,
  • Marcello Zala,
  • Daniel Croll

DOI
https://doi.org/10.1038/s41467-021-23862-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Structural variation in genomes of the same species is frequent but what drives the rearrangements remains unclear. Machine-learning of rearrangement patterns among telomere-to-telomere assemblies can accurately identify regions of intrinsic DNA instability in a eukaryotic pathogen.