Histamine antagonists promote cancer immunosurveillance

Abstract

ABSTRACTRecently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype and to increase their anticancer activity in the context of immunochemotherapy.

Keywords

• cancer
• cell death
• immunotherapy