Amplification and attenuation of lung metastases depending on glucocorticoid dosage implicating long‐acting activated memory cells induced by nivolumab against malignant melanoma

Abstract

Abstract Firstly, glucocorticoids such as prednisolone can attenuate the effect of anti–PD‐1 antibody nivolumab. Secondly, malignant melanoma cells survived latently and unnoticeably in places other than those of previous metastatic lesions. Thirdly, effector T cells activated by nivolumab sustained their memory to attack malignant melanoma cells for several months.

Keywords

• glucocorticoids
• interstitial pneumonitis
• lung metastasis
• mucosal malignant melanoma
• nivolumab