Revista da Sociedade Brasileira de Medicina Tropical (Jan 2023)

Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study

  • Otavio Sarmento Pieri,
  • Fernando Schemelzer Moraes Bezerra,
  • Paulo Marcos Zech Coelho,
  • Martin Johannes Enk,
  • Tereza Cristina Favre,
  • Carlos Graeff-Teixeira,
  • Ricardo Riccio Oliveira,
  • Mitermayer Galvão dos Reis,
  • Lee Senhorinha de Almeida Andrade,
  • Lilian Christina Nóbrega Holsbach Beck,
  • Vivian Favero,
  • Thainá Rodrigues de Souza Fialho,
  • Ricardo José de Paula Souza e Guimarães,
  • Bruna Souza Santos Oliveira,
  • Vanessa Fey Pascoal,
  • Marta Cristhiany Cunha Pinheiro,
  • Ronald Alves dos Santos,
  • Luciano Kalabric Silva,
  • Isadora Cristina de Siqueira,
  • Renata Perotto de Souza,
  • Naftale Katz

DOI
https://doi.org/10.1590/0037-8682-0238-2022
Journal volume & issue
Vol. 56

Abstract

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ABSTRACT Background: The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. Methods: Residents from eight sites with different prevalence estimates provided one urine sample for POC-ECO and one stool sample for Kato-Katz (KK) and Helmintex® (HTX) testing as an egg-detecting reference for infection status. Results: None of the study sites had significantly higher POC-ECO accuracy than KK. Conclusions: POC-ECO is not currently recommended in Brazilian schistosomiasis elimination programs.

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