Four-Component Reaction between Ethyl Benzoylacetate, Hydroxylamine, Aldehydes and Malononitrile: Synthesis of Isoxazol-5(2H)-Ones

Abstract

We present herein a new and efficient four-component synthesis of isoxazol-5(2H)-ones involving ring closing/Knoevenagel condensation/Michael addition sequential reactions.

Keywords

• hydroxylamine
• aromatic aldehyde
• malononitrile
• isoxazol-5(2h)-ones
• multi-component reactions
• green chemistry