Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats

Abstract

How the liver mitochondria seamlessly regulate lipogenesis and lipid oxidation is unknown. Here, the authors report two functionally distinct populations of mitochondria, cytoplasmic and lipid droplet-associated mitochondria, and demonstrate that the latter’s lipid oxidation function is impaired in a rat NAFLD model.