Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis

Fang Fang; Sa Wang; Yueyue Song; Meng Sun; Wen-Cheng Chen; Dongxu Zhao; Jinfeng Zhang

doi:10.1038/s41467-023-37315-0

Nature Communications (Mar 2023)

Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis

Fang Fang,
Sa Wang,
Yueyue Song,
Meng Sun,
Wen-Cheng Chen,
Dongxu Zhao,
Jinfeng Zhang

Affiliations

Fang Fang: Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology
Sa Wang: Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology
Yueyue Song: Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology
Meng Sun: Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology
Wen-Cheng Chen: School of Chemical Engineering and Light Industry, Guangdong University of Technology
Dongxu Zhao: Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology
Jinfeng Zhang: Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology

DOI: https://doi.org/10.1038/s41467-023-37315-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 14

Abstract

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Nanomedicine is important in cancer therapy, but loading, drug release, and therapeutic effectiveness issues limit the translation to the clinic. Here, authors report a full-API nanodrug with an ideal API content and pH-responsive release for continuous spatiotemporal cancer therapy based on PpIX-heme-CO/Fe2+/BV-BR metabolic pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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