The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects

Anjana Srivatsan; Bin-Zhong Li; Barnabas Szakal; Dana Branzei; Christopher D. Putnam; Richard D. Kolodner

doi:10.1038/s41467-018-06131-2

Nature Communications (Sep 2018)

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects

Anjana Srivatsan,
Bin-Zhong Li,
Barnabas Szakal,
Dana Branzei,
Christopher D. Putnam,
Richard D. Kolodner

Affiliations

Anjana Srivatsan: Ludwig Institute for Cancer Research, University of California School of Medicine
Bin-Zhong Li: Ludwig Institute for Cancer Research, University of California School of Medicine
Barnabas Szakal: The FIRC Institute of Molecular Oncology Foundation
Dana Branzei: The FIRC Institute of Molecular Oncology Foundation
Christopher D. Putnam: Ludwig Institute for Cancer Research, University of California School of Medicine
Richard D. Kolodner: Ludwig Institute for Cancer Research, University of California School of Medicine

DOI: https://doi.org/10.1038/s41467-018-06131-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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SWR-C and its substrate the histone variant Htz1 are considered important for genome maintenance. Here the authors reveal that SWR-C/Htz1 plays a critical role during replication stress caused by absence of the replication fork progression proteins Mrc1/Tof1/Csm3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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