Nature Communications (Feb 2018)
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin
- Manuel Rodríguez-Paredes,
- Felix Bormann,
- Günter Raddatz,
- Julian Gutekunst,
- Carlota Lucena-Porcel,
- Florian Köhler,
- Elisabeth Wurzer,
- Katrin Schmidt,
- Stefan Gallinat,
- Horst Wenck,
- Joachim Röwert-Huber,
- Evgeniya Denisova,
- Lars Feuerbach,
- Jeongbin Park,
- Benedikt Brors,
- Esther Herpel,
- Ingo Nindl,
- Thomas G. Hofmann,
- Marc Winnefeld,
- Frank Lyko
Affiliations
- Manuel Rodríguez-Paredes
- Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center
- Felix Bormann
- Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center
- Günter Raddatz
- Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center
- Julian Gutekunst
- Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center
- Carlota Lucena-Porcel
- Institute of Pathology, Heidelberg University
- Florian Köhler
- Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center
- Elisabeth Wurzer
- Research & Development, Beiersdorf AG
- Katrin Schmidt
- Research & Development, Beiersdorf AG
- Stefan Gallinat
- Research & Development, Beiersdorf AG
- Horst Wenck
- Research & Development, Beiersdorf AG
- Joachim Röwert-Huber
- Department of Dermatology, Venereology and Allergy, Charité, University Hospital
- Evgeniya Denisova
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Lars Feuerbach
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Jeongbin Park
- Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ)
- Benedikt Brors
- Division of Applied Bioinformatics, German Cancer Research Center (DKFZ)
- Esther Herpel
- Institute of Pathology, Heidelberg University
- Ingo Nindl
- Department of Dermatology, Venereology and Allergy, Charité, University Hospital
- Thomas G. Hofmann
- Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center
- Marc Winnefeld
- Research & Development, Beiersdorf AG
- Frank Lyko
- Division of Epigenetics, DKFZ-ZMBH Alliance, German Cancer Research Center
- DOI
- https://doi.org/10.1038/s41467-018-03025-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages.
