PUMILIO proteins promote colorectal cancer growth via suppressing p21

Yuanyuan Gong; Zukai Liu; Yihang Yuan; Zhenzhen Yang; Jiawei Zhang; Qin Lu; Wei Wang; Chao Fang; Haifan Lin; Sanhong Liu

doi:10.1038/s41467-022-29309-1

Nature Communications (Mar 2022)

PUMILIO proteins promote colorectal cancer growth via suppressing p21

Yuanyuan Gong,
Zukai Liu,
Yihang Yuan,
Zhenzhen Yang,
Jiawei Zhang,
Qin Lu,
Wei Wang,
Chao Fang,
Haifan Lin,
Sanhong Liu

Affiliations

Yuanyuan Gong: Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
Zukai Liu: Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
Yihang Yuan: Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine (SJTU-SM)
Zhenzhen Yang: Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
Jiawei Zhang: Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
Qin Lu: Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine (SJTU-SM)
Wei Wang: Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
Chao Fang: Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine (SJTU-SM)
Haifan Lin: The Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine
Sanhong Liu: Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University

DOI: https://doi.org/10.1038/s41467-022-29309-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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RNA binding proteins can contribute to colorectal cancer (CRC) initiation and development. Here the authors show that PUMILIO proteins, PUM1 and PUM2 contribute to CRC growth by inhibiting p21 expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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