P135: X-linked Alport syndrome: From transcriptomic diagnosis to preclinical assessment of splice-switching oligonucleotide therapy using patient-derived cells and kidney organoids*

• Hassan Saei,
• Marie Boisson,
• Christelle Arrondel,
• Bruno Estebe,
• Nicolas Cagnard,
• Marc Bras,
• Vincent Morinière,
• Zaïna Aït Arkoub,
• Laurence Heidet,
• Olivier Gribouval,
• Patrick Nitschké,
• Corinne Antignac,
• Géraldine Mollet,
• Guillaume Dorval

Affiliations

Hassan Saei

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Marie Boisson

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Christelle Arrondel

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Bruno Estebe

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Nicolas Cagnard

Bioinformatics Platform, Imagine Institute, Paris, France

Marc Bras

Bioinformatics Platform, Imagine Institute, Paris, France

Vincent Morinière

Medical Genetics Services for Rare Diseases, Necker Children Hospital, Paris, France

Zaïna Aït Arkoub

Medical Genetics Services for Rare Diseases, Necker Children Hospital, Paris, France

Laurence Heidet

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Olivier Gribouval

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Patrick Nitschké

Bioinformatics Platform, Imagine Institute, Paris, France

Corinne Antignac

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Géraldine Mollet

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France

Guillaume Dorval

Laboratory of Hereditary Kidney Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Paris, France