PLoS ONE (Jan 2017)

Haplotype dependent association of rs7927894 (11q13.5) with atopic dermatitis and chronic allergic rhinitis: A study in ECAP cohort.

  • Joanna Kinga Ponińska,
  • Bolesław Samoliński,
  • Aneta Tomaszewska,
  • Filip Raciborski,
  • Piotr Samel-Kowalik,
  • Artur Walkiewicz,
  • Agnieszka Lipiec,
  • Barbara Piekarska,
  • Edyta Krzych-Fałta,
  • Andrzej Namysłowski,
  • Grażyna Kostrzewa,
  • Andrzej Pawlik,
  • Monika Jasek,
  • Andrzej Wiśniewski,
  • Piotr Kuśnierczyk,
  • Sławomir Majewski,
  • Rafał Płoski

DOI
https://doi.org/10.1371/journal.pone.0183922
Journal volume & issue
Vol. 12, no. 9
p. e0183922

Abstract

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The T allele of rs7927894 (at 11q13.5) was associated with atopic dermatitis and other allergic diseases. Our purpose was to replicate the association with allergic phenotypes and explore the role of rs7927894 in predisposing to persistent allergic rhinitis and atopic asthma. We also wanted to explore if other SNPs at 11q13.5 contributed to effect of rs7927894. We studied patients with atopic dermatitis (N = 270), atopic asthma (N = 486), persistent allergic rhinitis (N = 589) and controls matched for age, sex and region (N = 540, N = 372 and N = 1178, respectively). We found that rs7927894 T was associated with atopic dermatitis (OR = 1.39, CI: 1.12-1.73, P = 0.003) and independently with persistent allergic rhinitis (OR = 1.24, CI:1.07-1.43, P = 0.0043, Pcorrected = 0.013) but not atopic asthma. Analysis of additional tagging SNPs (rs7930763, rs2513517, rs7125552) showed that effect of rs7927894 T was limited to haplotypes encoding G at rs7125552. In conclusion, rs7927894 T is associated not only with atopic dermatitis but also persistent allergic rhinitis. Since these effects are haplotype dependent rs7927894 alone does not account for the association between 11q13.5 and atopic dermatitis/persistent allergic rhinitis.