Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

Ming Zhai; Shiyu Gong; Peipei Luan; Yefei Shi; Wenxin Kou; Yanxi Zeng; Jiayun Shi; Guanye Yu; Jiayun Hou; Qing Yu; Weixia Jian; Jianhui Zhuang; Mark W. Feinberg; Wenhui Peng

doi:10.1038/s41467-022-35330-1

Nature Communications (Dec 2022)

Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis

Ming Zhai,
Shiyu Gong,
Peipei Luan,
Yefei Shi,
Wenxin Kou,
Yanxi Zeng,
Jiayun Shi,
Guanye Yu,
Jiayun Hou,
Qing Yu,
Weixia Jian,
Jianhui Zhuang,
Mark W. Feinberg,
Wenhui Peng

Affiliations

Ming Zhai: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Shiyu Gong: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Peipei Luan: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Yefei Shi: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Wenxin Kou: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Yanxi Zeng: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Jiayun Shi: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Guanye Yu: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Jiayun Hou: Biomedical Research Center, Zhongshan Hospital Institute of Clinical Science, Fudan University
Qing Yu: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Weixia Jian: Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine
Jianhui Zhuang: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine
Mark W. Feinberg: Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School
Wenhui Peng: Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine

DOI: https://doi.org/10.1038/s41467-022-35330-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Vascular smooth muscle cells (VSMCs) are known for their fate plasticity in atherosclerosis plaque progression. Here, Zhai et al. show that extracellular traps generated from CD68 + VSMCs adversely contribute to plaque progression and highlight their unexpected role in plaque stability by regulating the direction of VSMC trans-differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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