A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

Yan Ting Shue; Alexandros P. Drainas; Nancy Yanzhe Li; Sarah M. Pearsall; Derrick Morgan; Nasa Sinnott-Armstrong; Susan Q. Hipkins; Garry L. Coles; Jing Shan Lim; Anthony E. Oro; Kathryn L. Simpson; Caroline Dive; Julien Sage

doi:10.1038/s41467-022-30416-2

Nature Communications (May 2022)

A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

Yan Ting Shue,
Alexandros P. Drainas,
Nancy Yanzhe Li,
Sarah M. Pearsall,
Derrick Morgan,
Nasa Sinnott-Armstrong,
Susan Q. Hipkins,
Garry L. Coles,
Jing Shan Lim,
Anthony E. Oro,
Kathryn L. Simpson,
Caroline Dive,
Julien Sage

Affiliations

Yan Ting Shue: Departments of Pediatrics, Stanford University
Alexandros P. Drainas: Departments of Pediatrics, Stanford University
Nancy Yanzhe Li: Departments of Program in Epithelial Biology, Stanford University
Sarah M. Pearsall: Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
Derrick Morgan: Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
Nasa Sinnott-Armstrong: Departments of Genetics, Stanford University
Susan Q. Hipkins: Departments of Pediatrics, Stanford University
Garry L. Coles: Departments of Pediatrics, Stanford University
Jing Shan Lim: Departments of Pediatrics, Stanford University
Anthony E. Oro: Departments of Program in Epithelial Biology, Stanford University
Kathryn L. Simpson: Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
Caroline Dive: Cancer Research UK Manchester Institute Cancer Biomarker Centre, University of Manchester
Julien Sage: Departments of Pediatrics, Stanford University

DOI: https://doi.org/10.1038/s41467-022-30416-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Notch signaling is known to control neuroendocrine fate in the lungs. Shue and colleagues further identify the REST and YAP transcriptional regulators as key components of the Notch signaling pathway in the control of the neuroendocrine cell fate in lung development, lung injury response, and small-cell lung cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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