A carbohydrate approach for the formal total synthesis of (−)-aspergillide C

Abstract

An enantioselective formal total synthesis of aspergillide C is accomplished using commercially available tri-O-acetyl-D-galactal employing a Ferrier-type C-glycosylation, utilizing a Trost hydrosilylation and protodesilylation as key reactions.

Keywords

• alkynylation
• chiron approach
• Ferrier-type C-glycosylation
• macrolide