Nature Communications (Mar 2020)
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
- Olivia J. S. Macleod,
- Jean-Mathieu Bart,
- Paula MacGregor,
- Lori Peacock,
- Nicholas J. Savill,
- Svenja Hester,
- Sophie Ravel,
- Jack D. Sunter,
- Camilla Trevor,
- Steven Rust,
- Tristan J. Vaughan,
- Ralph Minter,
- Shabaz Mohammed,
- Wendy Gibson,
- Martin C. Taylor,
- Matthew K. Higgins,
- Mark Carrington
Affiliations
- Olivia J. S. Macleod
- Department of Biochemistry, University of Cambridge
- Jean-Mathieu Bart
- Intertryp, IRD, Cirad, University of Montpellier
- Paula MacGregor
- Department of Biochemistry, University of Cambridge
- Lori Peacock
- School of Biological Sciences, University of Bristol
- Nicholas J. Savill
- Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh
- Svenja Hester
- Department of Biochemistry, University of Oxford
- Sophie Ravel
- Intertryp, IRD, Cirad, University of Montpellier
- Jack D. Sunter
- Department of Biological and Medical Sciences, Oxford Brookes University
- Camilla Trevor
- Department of Biochemistry, University of Cambridge
- Steven Rust
- Department of Antibody Discovery and Protein Engineering, AstraZeneca R&D
- Tristan J. Vaughan
- Department of Antibody Discovery and Protein Engineering, AstraZeneca R&D
- Ralph Minter
- Department of Antibody Discovery and Protein Engineering, AstraZeneca R&D
- Shabaz Mohammed
- Department of Biochemistry, University of Oxford
- Wendy Gibson
- School of Biological Sciences, University of Bristol
- Martin C. Taylor
- Faculty of Infectious and Tropical diseases, London School of Hygiene and Tropical Medicine
- Matthew K. Higgins
- Department of Biochemistry, University of Oxford
- Mark Carrington
- Department of Biochemistry, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-020-15125-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, that increases parasite transmission to tsetse flies.
