Nature Communications (Oct 2016)

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

  • Marco Giardiello,
  • Neill J. Liptrott,
  • Tom O. McDonald,
  • Darren Moss,
  • Marco Siccardi,
  • Phil Martin,
  • Darren Smith,
  • Rohan Gurjar,
  • Steve P. Rannard,
  • Andrew Owen

DOI
https://doi.org/10.1038/ncomms13184
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Nanomedicine efficacy in a clinical setting depends on the pharmacological properties of the therapeutic nanoparticles. Here, the authors exemplify an accelerated translational strategy from small-scale screening to clinical scale-up for an orally-dosed aqueous paediatric HIV nanomedicine.