Evaluation of Efficacy of Nasal Sprays Containing Mometasone Furoate and Azelastine Hydrochloride in the Management of Allergic Rhinitis

Abstract

Objectives:To evaluate and compare the efficacy of mometasone furoate and azelastine nasal sprays in allergic rhinitis.Materials and Methods:Ninety two patients with sneezing, nasal obstruction and rhinorrhea symptoms diagnosed as allergic rhinitis by physical examination, skin and blood test were included in this study. Forty-six patients (Group I) were treated with mometasone furoate, in the other forty-six patients (Group II) were treated with azelastine hydrochloride nasal sprays. The effect of administered treatment on sneezing, nasal congestion, concha edema and rhinorrhea were compared statistically.Results:60.8% (58 patients) of study group had perennial allergic rhinitis. The most common complaint of patients was nasal obstruction. Allergens were dust mite in 69 patients (75%). In the control of patients on the 5, 10 and 30th days, statistically significant improvement was observed in Group I versus Group II (p<0.005). Statistically significant relief of sneezing, rhinorrhea and nasal pruritus from seasonal allergic rhinitis in the Group II (p<0.005).Conclusion:In this study, the mometasone furoate nasal sprays was observed superior to the azelastine sprays according to resolution of complaints and signs of allergic rhinitis patients. On the other hand, especially in the treatment of complaints of patients with seasonal allergic rhinitis such as sneezing, rhinorrhea and pruritus early and meaningful relief was observed by azelastine treatment.

Keywords

• allergic rhinitis
• topical nasal steroid
• topical antihistamines
• diagnosis.