The mechanical proprieties, corrosion, and biocompatibility of pure titanium were improved by reinforcing with 12 wt.% molybdenum and different weight percentages of zirconia. Powder metallurgy technique is applied to achieve a good homogeneous distribution of Mo and ZrO2 in the titanium matrix. The correlation between the microstructure, properties like density hardness, wear rates, corrosion resistance, and the biocompatibility of the fabricated Ti–12Mo/ZrO2 composites were studied. The results indicate that the density of the pure Ti was increased by adding 12 wt.% Mo as well as by increasing the ZrO2 percentage up to 5 wt.%. The eutectoid phase has been formed as a result of reinforcing the titanium matrix by 12 wt.% Mo. The highest hardness and the lowest wear rate were observed for 5 wt.% ZrO2 sample. The Ti–12Mo/(x)ZrO2 composites show high corrosion resistance in the simulated saliva fluid (SSF). The measured concentrations of both Ti, Mo, and Zr ions released in SSF from Ti–12Mo/(x)ZrO2 nanocomposites were extremely low. The results demonstrated that Ti–12Mo/5 wt.%ZrO2 composites have high potential applications in dental implantation. The biocompatibility test was estimated for all samples. The results also revealed that the high adhesion and growth of live cells achieve on the 5 wt.% ZrO2 sample.