NFLUENCE OF CHRONIC ALCOHOLIC INTOXICATION ON ORGANIZATIONOF SOME CIRCADIAN RHYTHMS OF ORGANISM OF ONE-YEAR-OLDFEMALE WISTAR RATS

Abstract

Purpose. We study the effect of chronic alcohol intoxication on some biochemical and hematological parameters of the mammalian organism and the structure of the daily dynamics of these parameters. Procedure and research methods. The daily dynamics of biochemical and hematological parameters in one-year-old female Wistar rats is compared at norm and in the condition of chronic alcohol intoxication. Results of the study. It is found that chronic alcohol intoxication leads a number of significant changes in the biochemical and hematological profile of rats. Chronotoxicity of alcohol in the applied dosage in relation to the circadian rhythms of a significant part of the studied parameters is revealed. Theoretical / practical significance. New data on the negative effect of alcohol on the mammalian organism, represented by its chronotoxic effect, are obtained.

Keywords

• circadian rhythms
• alcohol
• desynchronosis
• light regime