Journal of Cutaneous Immunology and Allergy (Dec 2022)

Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini‐review

  • Eri Hotta,
  • Risa Tamagawa‐Mineoka,
  • Yuri Onishi,
  • Ayaka Sotozono,
  • Megumi Kusunoki,
  • Junko Hattori,
  • Natsue Ioka,
  • Hiromi Mizutani,
  • Koji Masuda,
  • Norito Katoh

DOI
https://doi.org/10.1002/cia2.12261
Journal volume & issue
Vol. 5, no. 6
pp. 217 – 221

Abstract

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Abstract Excipient allergies are rare and difficult to diagnose. Carboxymethylcellulose (CMC, carmellose sodium) is an anionic water‐soluble polymer derived from native cellulose, that is, used as an excipient. Here, we report a case of urticaria caused by the CMC in lidocaine jelly and dimethicone drops, which had used for upper gastrointestinal endoscopy. CMC is widely used in pharmaceutical preparations, food additives, and other pharmaceuticals, and its use is increasing. However, there are few reports on immediate hypersensitivity reactions because substances containing CMC. Previous reports and our case suggest that excipients, such as CMC, can be potential hidden allergens.

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