Structure of the planar cell polarity cadherins Fat4 and Dachsous1

Elliot Medina; Yathreb Easa; Daniel K. Lester; Eric K. Lau; David Sprinzak; Vincent C. Luca

doi:10.1038/s41467-023-36435-x

Nature Communications (Feb 2023)

Structure of the planar cell polarity cadherins Fat4 and Dachsous1

Elliot Medina,
Yathreb Easa,
Daniel K. Lester,
Eric K. Lau,
David Sprinzak,
Vincent C. Luca

Affiliations

Elliot Medina: Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute
Yathreb Easa: School of Neurobiology, Biochemistry, and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University
Daniel K. Lester: Cancer Biology Ph.D Program, University of South Florida
Eric K. Lau: Department of Tumor Biology, H. Lee Moffitt Cancer Center & Research Institute
David Sprinzak: School of Neurobiology, Biochemistry, and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University
Vincent C. Luca: Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute

DOI: https://doi.org/10.1038/s41467-023-36435-x
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

Read online

Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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