The Chromatin Structure Differentially Impacts High-Specificity CRISPR-Cas9 Nuclease Strategies

• Xiaoyu Chen,
• Jin Liu,
• Josephine M. Janssen,
• Manuel A.F.V. Gonçalves

Affiliations

Xiaoyu Chen

Department of Molecular Cell Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, the Netherlands

Jin Liu

Department of Molecular Cell Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, the Netherlands

Josephine M. Janssen

Department of Molecular Cell Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, the Netherlands

Manuel A.F.V. Gonçalves

Department of Molecular Cell Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, the Netherlands; Corresponding author: Manuel A.F.V. Gonçalves, Department of Molecular Cell Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, the Netherlands.