Crowberry inhibits cell proliferation and migration through a molecular mechanism that includes inhibition of DEK and Akt signaling in cholangiocarcinoma

Abstract

Highlights 1. Crowberry alterd expression levels of key mediators in PI3K/Akt signaling pathway. 2. Crowberry alterd expression levels of key mediators in PI3K/Akt signaling pathway. 3. Crowberry suppressed the expression of the proto-oncogene DEK in vivo and in vitro. 4. Crowberry inhibited CCA progression and migration through a molecular mechanism that includes inhibition of DEK and the Akt signaling pathway in vivo and in vitro.

Keywords

• Cholangiocarcinoma
• Empetrum nigrum var. japonicum
• Proliferation
• Migration
• DEK