Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
Mariana Grecu,
Bogdan Minea,
Liliana-Georgeta Foia,
Andra-Cristina Bostanaru-Iliescu,
Liviu Miron,
Valentin Nastasa,
Mihai Mares
Affiliations
Mariana Grecu
Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Life Sciences of Iasi (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania
Bogdan Minea
Department of Surgery, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, 16 Universitatii Street, 700115 Iași, Romania
Liliana-Georgeta Foia
Department of Surgery, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, 16 Universitatii Street, 700115 Iași, Romania
Andra-Cristina Bostanaru-Iliescu
Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Life Sciences of Iasi (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania
Liviu Miron
Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Life Sciences of Iasi (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania
Valentin Nastasa
Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Life Sciences of Iasi (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania
Mihai Mares
Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Life Sciences of Iasi (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania
Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The benefits of these complexes are directed towards improving the chemical and biological properties—i.e., solubility, bioavailability, stability, non-toxicity and shelf life of drug molecules. Since the 1960s, the first inclusion complexes used in therapeutics were those with α-, β- and γ-CD, which proved their usefulness, but had certain degrees of particularly renal toxicity. Currently, to correct these deficiencies, β-CD derivatives are most frequently used, such as sulfobutylether-β-CD, hydroxypropyl-β-CD, etc. Therefore, it is of interest to bring to the attention of those interested the diversity of current and potential future clinical applications of inclusion complexes in veterinary medicine and to present the contribution of these inclusion complexes in improving drug efficacy. The most important biological activities of β-CD complexed molecules in the veterinary field are summarized in this short review.