Clinical, Cosmetic and Investigational Dermatology (Aug 2019)

Assessment of macrophage migration inhibitory factor in patients with verruca vulgaris

  • Sorour NE,
  • Hamed AM,
  • Tabl HAEM,
  • Ahmed AAEA

Journal volume & issue
Vol. Volume 12
pp. 591 – 595

Abstract

Read online

Neveen Emad Sorour,1 Ahmed Mohamed Hamed,1 Hala Abd-El Mageed Tabl,2 Amira Abd-El Aziz Ahmed11Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha Univesity, Benha, Egypt; 2Department of Medical Microbiology and Immunology, Faculty of Medicine, Benha Univesity, Benha, EgyptCorrespondence: Ahmed Mohamed HamedDepartment of Dermatology, Venereology and Andrology Faculty of Medicine, Benha University, El Kobry street, No.5, Benha 13513, EgyptTel +20 0 100 523 9888Email ahmedhamed06@yahoo.comBackground: Common warts are caused by human papillomaviruses (HPVs), they are among the most common cutaneous viral infections. Macrophage migration inhibitory factor (MIF) is an essential contributor in many inflammatory and immune skin diseases. Yet, its role in the pathology of common warts is unclear.Objective: To assess MIF levels in lesional and perilesional skin in patients with common warts in comparison to apparently healthy control group with matching age and sex.Subjects and methods: A case-control study performed on 60 patients with common warts (group A) and 30 age and sex matching healthy controls (group B). Two biopsies were taken from each patient in group A; one from the lesion (lesional) and the other one from the skin around the wart (perilesional), while biopsies of controls were taken from matched sites to patients. Measurement of MIF in all groups was done by quantitative ELISA kits.Results: Significant high MIF levels were detected in lesional and perilesional skin biopsies compared to controls (P<0.001). Yet, the difference in MIF levels between lesional and perilesional skin biopsy was non-significant. No significant relations were found between lesional and perilesional MIF levels and clinical characteristics of the studied patients while both lesional and perilesional MIF levels were significantly correlated (rh=0.269, P=0.021).Conclusion: The significantly elevated MIF levels in lesional and perilesional skin biopsies compared to controls point to its role in wart progression from HPV infected cells.Keywords: macrophage migration inhibitory factor, common warts, human papillomavirus  

Keywords