Nature Communications (Jul 2022)
Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration
- Anne Senabouth,
- Maciej Daniszewski,
- Grace E. Lidgerwood,
- Helena H. Liang,
- Damián Hernández,
- Mehdi Mirzaei,
- Stacey N. Keenan,
- Ran Zhang,
- Xikun Han,
- Drew Neavin,
- Louise Rooney,
- Maria Isabel G. Lopez Sanchez,
- Lerna Gulluyan,
- Joao A. Paulo,
- Linda Clarke,
- Lisa S. Kearns,
- Vikkitharan Gnanasambandapillai,
- Chia-Ling Chan,
- Uyen Nguyen,
- Angela M. Steinmann,
- Rachael A. McCloy,
- Nona Farbehi,
- Vivek K. Gupta,
- David A. Mackey,
- Guy Bylsma,
- Nitin Verma,
- Stuart MacGregor,
- Matthew J. Watt,
- Robyn H. Guymer,
- Joseph E. Powell,
- Alex W. Hewitt,
- Alice Pébay
Affiliations
- Anne Senabouth
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Maciej Daniszewski
- Department of Anatomy and Physiology, The University of Melbourne
- Grace E. Lidgerwood
- Department of Anatomy and Physiology, The University of Melbourne
- Helena H. Liang
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Damián Hernández
- Department of Anatomy and Physiology, The University of Melbourne
- Mehdi Mirzaei
- Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
- Stacey N. Keenan
- Department of Anatomy and Physiology, The University of Melbourne
- Ran Zhang
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Xikun Han
- QIMR Berghofer Medical Research Institute
- Drew Neavin
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Louise Rooney
- Department of Anatomy and Physiology, The University of Melbourne
- Maria Isabel G. Lopez Sanchez
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Lerna Gulluyan
- Department of Anatomy and Physiology, The University of Melbourne
- Joao A. Paulo
- Department of Cell Biology, Harvard Medical School
- Linda Clarke
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Lisa S. Kearns
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Vikkitharan Gnanasambandapillai
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Chia-Ling Chan
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Uyen Nguyen
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Angela M. Steinmann
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Rachael A. McCloy
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Nona Farbehi
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Vivek K. Gupta
- Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University
- David A. Mackey
- Lions Eye Institute, Centre for Vision Sciences, University of Western Australia
- Guy Bylsma
- Lions Eye Institute, Centre for Vision Sciences, University of Western Australia
- Nitin Verma
- School of Medicine, University of Tasmania
- Stuart MacGregor
- QIMR Berghofer Medical Research Institute
- Matthew J. Watt
- Department of Anatomy and Physiology, The University of Melbourne
- Robyn H. Guymer
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Joseph E. Powell
- Garvan-Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research
- Alex W. Hewitt
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital
- Alice Pébay
- Department of Anatomy and Physiology, The University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-022-31707-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Age-related macular degeneration (AMD) is a leading cause of vision loss, and there is no approved treatment for AMD with geographic atrophy. Here, the authors used transcriptomic and proteomic analyses of patient induced pluripotent stem cell-derived retinal pigment epithelium to better understand disease mechanisms.
