BMC Oral Health (May 2022)
Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the SIPMO (Italian Society of Oral Pathology and Medicine)
- Daniela Adamo,
- Elena Calabria,
- Federica Canfora,
- Noemi Coppola,
- Lorenzo Lo Muzio,
- Francesca Spirito,
- Michele Giuliani,
- Lorenzo Azzi,
- Vittorio Maurino,
- Giuseppe Colella,
- Chiara Colella,
- Lucio Montebugnoli,
- Davide Bartolomeo Gissi,
- Mario Gabriele,
- Marco Nisi,
- Andrea Sardella,
- Giovanni Lodi,
- Elena Maria Varoni,
- Amerigo Giudice,
- Alessandro Antonelli,
- Paolo Giacomo Arduino,
- Alessio Gambino,
- Paolo Vescovi,
- Alessandra Majorana,
- Elena Bardellini,
- Giuseppina Campisi,
- Vera Panzarella,
- Francesco Spadari,
- Umberto Garagiola,
- Monica Pentenero,
- Samuele Sutera,
- Matteo Biasotto,
- Giulia Ottaviani,
- Margherita Gobbo,
- Luca Guarda Nardini,
- Umberto Romeo,
- Gianluca Tenore,
- Rosario Serpico,
- Alberta Lucchese,
- Carlo Lajolo,
- Cosimo Rupe,
- Massimo Aria,
- Luca D’Aniello,
- Michele Davide Mignogna,
- SIPMO (Italian Society of Oral Pathology and Medicine)
Affiliations
- Daniela Adamo
- Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II
- Elena Calabria
- Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II
- Federica Canfora
- Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II
- Noemi Coppola
- Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II
- Lorenzo Lo Muzio
- Department of Clinical and Experimental Medicine, University of Foggia
- Francesca Spirito
- Department of Clinical and Experimental Medicine, University of Foggia
- Michele Giuliani
- Department of Clinical and Experimental Medicine, University of Foggia
- Lorenzo Azzi
- Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria
- Vittorio Maurino
- Unit of Oral Medicine and Pathology, ASST dei Sette Laghi, Department of Medicine and Surgery, University of Insubria
- Giuseppe Colella
- Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli
- Chiara Colella
- Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli
- Lucio Montebugnoli
- Department of Biomedical and Neuromotor Sciences, Section of Oral Sciences, University of Bologna
- Davide Bartolomeo Gissi
- Department of Biomedical and Neuromotor Sciences, Section of Oral Sciences, University of Bologna
- Mario Gabriele
- Department of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa
- Marco Nisi
- Department of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa
- Andrea Sardella
- Department of Biomedical, Surgical and Dental Sciences, University of Milan
- Giovanni Lodi
- Department of Biomedical, Surgical and Dental Sciences, University of Milan
- Elena Maria Varoni
- Department of Biomedical, Surgical and Dental Sciences, University of Milan
- Amerigo Giudice
- Department of Health Sciences, Magna Graecia University of Catanzaro
- Alessandro Antonelli
- Department of Health Sciences, Magna Graecia University of Catanzaro
- Paolo Giacomo Arduino
- Oral Medicine Section, Department of Surgical Science, CIR Dental School, University of Turin
- Alessio Gambino
- Oral Medicine Section, Department of Surgical Science, CIR Dental School, University of Turin
- Paolo Vescovi
- Department of Medicine and Surgery, Oral Medicine and Laser Surgery Unit, University Center of Dentistry, University of Parma
- Alessandra Majorana
- Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia
- Elena Bardellini
- Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia
- Giuseppina Campisi
- Department of Surgical, Oncological, and Oral Sciences, University of Palermo
- Vera Panzarella
- Department of Surgical, Oncological, and Oral Sciences, University of Palermo
- Francesco Spadari
- Department of Biomedical, Surgical and Dental Sciences, Maxillo-Facial and Dental Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan
- Umberto Garagiola
- Department of Biomedical, Surgical and Dental Sciences, Maxillo-Facial and Dental Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan
- Monica Pentenero
- Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin
- Samuele Sutera
- Department of Oncology, Oral Medicine and Oral Oncology Unit, University of Turin
- Matteo Biasotto
- Department of Medical, Surgical and Health Sciences, University of Trieste
- Giulia Ottaviani
- Department of Medical, Surgical and Health Sciences, University of Trieste
- Margherita Gobbo
- Department of Medical, Surgical and Health Sciences, University of Trieste
- Luca Guarda Nardini
- Unit of Oral and Maxillofacial Surgery, Ca’ Foncello Hospital
- Umberto Romeo
- Department of Oral Sciences and Maxillofacial Surgery, University of Rome La Sapienza
- Gianluca Tenore
- Department of Oral Sciences and Maxillofacial Surgery, University of Rome La Sapienza
- Rosario Serpico
- Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli
- Alberta Lucchese
- Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli
- Carlo Lajolo
- Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, School of Dentistry, Università Cattolica del Sacro Cuore
- Cosimo Rupe
- Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, School of Dentistry, Università Cattolica del Sacro Cuore
- Massimo Aria
- Department of Economics and Statistics, University Federico II of Naples
- Luca D’Aniello
- Department of Social Sciences, University Federico II of Naples
- Michele Davide Mignogna
- Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II
- SIPMO (Italian Society of Oral Pathology and Medicine)
- DOI
- https://doi.org/10.1186/s12903-022-02181-7
- Journal volume & issue
-
Vol. 22,
no. 1
pp. 1 – 16
Abstract
Abstract Background Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP. Methods 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. Results The Central-South K-OLP (CS-K-OLP) patients reported a higher frequency of pain/burning compared with the K-OLP patients of the North (N-K-OLP) with higher scores in the NRS and T-PRI (p value < 0.001**). The CS-K-OLP and the CS-nK-OLP patients showed higher scores in the HAM-D, HAM-A, PSQI and ESS compared with the Northern patients (p value < 0.001**). Multivariate logistic regression revealed that the NRS and T-PRI showed the greatest increase in the R2 value for the CS-K-OLP (DR2 = 9.6%; p value < 0.001**; DR2 = 9.7% p value < 0.001**; respectively) and that the oral symptoms (globus, itching and intraoral foreign body sensation) and PSQI showed the greatest increase in the R2 value for the CS-nK-OLP (DR2 = 5.6%; p value < 0.001**; DR2 = 4.5% p value < 0.001** respectively). Conclusions Pain and mood disorders are predominant in patients with OLP in the Central-South of Italy. Clinicians should consider that the geographical living area may explain the differences in oral symptoms and psychological profile in OLP.
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