Nature Communications (Jan 2018)
Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer
- Nalinikanth Kotagiri,
- Matthew L. Cooper,
- Michael Rettig,
- Christopher Egbulefu,
- Julie Prior,
- Grace Cui,
- Partha Karmakar,
- Mingzhou Zhou,
- Xiaoxia Yang,
- Gail Sudlow,
- Lynne Marsala,
- Chantiya Chanswangphuwana,
- Lan Lu,
- LeMoyne Habimana-Griffin,
- Monica Shokeen,
- Xinming Xu,
- Katherine Weilbaecher,
- Michael Tomasson,
- Gregory Lanza,
- John F. DiPersio,
- Samuel Achilefu
Affiliations
- Nalinikanth Kotagiri
- Department of Radiology, Washington University School of Medicine
- Matthew L. Cooper
- Department of Medicine, Washington University School of Medicine
- Michael Rettig
- Department of Medicine, Washington University School of Medicine
- Christopher Egbulefu
- Department of Radiology, Washington University School of Medicine
- Julie Prior
- Department of Radiology, Washington University School of Medicine
- Grace Cui
- Department of Medicine, Washington University School of Medicine
- Partha Karmakar
- Department of Radiology, Washington University School of Medicine
- Mingzhou Zhou
- Department of Radiology, Washington University School of Medicine
- Xiaoxia Yang
- Department of Medicine, Washington University School of Medicine
- Gail Sudlow
- Department of Radiology, Washington University School of Medicine
- Lynne Marsala
- Department of Radiology, Washington University School of Medicine
- Chantiya Chanswangphuwana
- Department of Medicine, Washington University School of Medicine
- Lan Lu
- Department of Medicine, Washington University School of Medicine
- LeMoyne Habimana-Griffin
- Department of Radiology, Washington University School of Medicine
- Monica Shokeen
- Department of Radiology, Washington University School of Medicine
- Xinming Xu
- Department of Medicine, Washington University School of Medicine
- Katherine Weilbaecher
- Department of Medicine, Washington University School of Medicine
- Michael Tomasson
- Department of Medicine, Washington University School of Medicine
- Gregory Lanza
- Department of Medicine, Washington University School of Medicine
- John F. DiPersio
- Department of Medicine, Washington University School of Medicine
- Samuel Achilefu
- Department of Radiology, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-02758-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Most of the systemic cancer therapies lack spatiotemporal control. Here, the authors show targeted activation of a light-sensitive drug by radiopharmaceuticals in disseminated cancer cells as potential in vivo treatment of metastatic diseases with reduced off-target toxicity.
