Indian Journal of Pathology and Microbiology (Jul 2008)

A clinicopathologic study of mantle cell lymphoma in a single center study in India

  • Gujral S,
  • Agarwal A,
  • Gota V,
  • Nair R,
  • Gupta S,
  • Pai S,
  • Sanger M,
  • Shet T,
  • Subramanian P,
  • Muckaden M,
  • Laskar S

Journal volume & issue
Vol. 51, no. 3
pp. 315 – 322

Abstract

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We present clinical features, histopathology and results of treatment in cases of mantle cell lymphoma (MCL) at our hospital. We had 93 cases (2.1%) of MCL out of total 4301 cases of non-Hodgkin′s lymphoma (NHL) in a 4-year period. It included 68 cases (1.7%) of MCL from 3987 cases of NHL diagnosed on histopathology. Remaining 25 cases (7.9%) diagnosed solely on peripheral blood examination were excluded. Thirty-six (85%) patients had advanced-stage disease. Sixty-three were nodal and five were extranodal (all gastrointestinal tract). Common patterns were diffuse (64%), nodular (25%) and mantle zone type (11%). Sixty-two cases had lymphocytic while six had blastic morphology (all nodal). Tumor cells expressed CD20 (100%), CD43 (94%), CD5 (89%) and cyclin D1 (85%). Bone marrow was involved in 25 (59%) cases. Thirty-two patients could be treated. Median recurrence-free survival was 22.23 months. Diffuse pattern of nodal involvement had a lower overall survival.

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