BMC Chemistry (Mar 2022)

Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF

  • Reza Akhavan-Sigari,
  • Malihe Zeraati,
  • Mohammadreza Moghaddam-Manesh,
  • Parya Kazemzadeh,
  • Sara Hosseinzadegan,
  • Narendra Pal Singh Chauhan,
  • Ghasem Sargazi

DOI
https://doi.org/10.1186/s13065-022-00804-2
Journal volume & issue
Vol. 16, no. 1
pp. 1 – 7

Abstract

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Abstract The ultrasonic assisted reverse micelle method (UARM) was used to synthesize Cu-MOF from Cu(NO3)2·3H2O and 2,6-pyridine dicarboxylic acid in a 1:1 molar proportion. It has been characterized using FT-IR, XRD, nitrogen adsorption analysis, SEM and TEM–EDX. The morphology of Cu-MOFs was spherical, with an average particle size distribution of less than 100 nm. Using BET analysis, the surface area of Cu-MOF was found to be 284.94 m2/g. The porous morphology of Cu-MOF was also suggested by SEM and TEM analyses. It has anticancer properties against MCF-7 breast cancer cells. Cytotoxicity testing was performed on MCF-7 breast cancer cells using the MTT cell viability assay, and cell proliferation and viability were found to be approximately 24% higher than the control.

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