Nature Communications (Jun 2018)

Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome

  • Yue Li,
  • Michael E. Stockton,
  • Brian E. Eisinger,
  • Yinghua Zhao,
  • Jessica L. Miller,
  • Ismat Bhuiyan,
  • Yu Gao,
  • Zhiping Wu,
  • Junmin Peng,
  • Xinyu Zhao

DOI
https://doi.org/10.1038/s41467-018-04869-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by reducing histone acetylation.