Nature Communications (Jun 2018)
Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome
Abstract
Loss of fragile X mental retardation protein (FMRP) leads to fragile X syndrome, associated with cognitive dysfunction. Here the authors show that mice lacking FMRP show reduced hippocampal neurogenesis and cognitive deficits, which can be rescued by reducing histone acetylation.