Nature Communications (Nov 2016)

Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism

  • Tatsuya Tamura,
  • Hiroshi Noda,
  • Eri Joyashiki,
  • Maiko Hoshino,
  • Tomoyuki Watanabe,
  • Masahiko Kinosaki,
  • Yoshikazu Nishimura,
  • Tohru Esaki,
  • Kotaro Ogawa,
  • Taiji Miyake,
  • Shinichi Arai,
  • Masaru Shimizu,
  • Hidetomo Kitamura,
  • Haruhiko Sato,
  • Yoshiki Kawabe

DOI
https://doi.org/10.1038/ncomms13384
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

Hypoparathyroidism and osteoporosis can be treated with parathyroid hormone, but frequent injections are required. Here the authors develop a small-molecule agonist for the parathyroid hormone type I receptor that can be administered orally, and demonstrate its efficacy in rats.